Our research findings enrich our knowledge about the biological functions of SelM and provide a theoretical basis for the lack of SelM leading to liver inflammation in chickens. In conclusion, selenium deficiency causes hepatitis by upregulating miR-138-5p targeting SelM. Hepatitis B can also be transmitted via objects that carry the virus because hepatitis B can survive outside the body for up to seven days. Importantly, ROS and the Ca 2+ inhibitor could effectively alleviate the energy metabolism disorder, necroptosis and inflammatory cytokine secretion caused by miR-138-5p overexpression and SelM knockdown in LMH cells. A case of transfusion-transmitted hepatitis E caused by blood from a donor infected with hepatitis E virus via zoonotic food-borne route. Persons with chronic hepatitis B virus (HBV) infection are at increased risk for liver cancer and cirrhosis and are 7085 more likely to die prematurely than the general population (14 5,6), two thirds of whom might be unaware of their infection. Oxidative stress, Ca 2+ overload, energy metabolism disorder and necroptosis occurred in chicken liver tissue. HAV transmission related to food could be the result of contamination at the point of service, usually by an infected food handler, or contamination during growing. The hepatitis B virus can be found in the blood, semen, and other body fluids of an infected person. We observed that Se deficiency resulted in liver inflammation, up-regulation of miR-138-5p expression and down-regulation of SelM expression in chickens. Prevention of hepatitis B and C transmission in health-care settings 95 10.5. ![]() ![]() However, about 1 in 20 people who get hepatitis B as adults become carriers, which means they have a chronic (long-lasting) hepatitis B infection. More than 9 out of 10 adults who get hepatitis B totally recover. Prevention of hepatitis B transmission and measures to reduce disease progression in persons with chronic hepatitis B 94 10.4. The good news is it usually goes away by itself in 4 to 8 weeks. Prevention of mother-to-child HBV transmission using antiviral therapy 89 10.3. Transmission electron microscopy, H&E staining, Fluo4-AM/ER staining, and flow cytometry were used to detect the morphological changes in chicken liver tissue and the expression changes of necroptosis and inflammation in chicken liver cells. Infant and neonatal hepatitis B vaccination 87 10.2. Can a person spread the hepatitis B virus and not know it. The miR-138-5p knockdown and overexpression models and SelM knockdown models were established in LMH cells for an in vitro study. Hepatitis B is not spread through sneezing, coughing, hugging, breastfeeding or through food or water. We established an in vivo chicken liver Se deficiency model by feeding a low-Se diet. ![]() However, the role of miR-138-5p/SelM and necroptosis in chicken SelM-deficient hepatitis and the specific biological mechanism of liver inflammation caused by SelM deficiency have not been elucidated. Selenoprotein M (SelM), a key thioredoxin like enzyme in the endoplasmic reticulum (ER), is closely related to hepatocyte degeneration.
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